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AwadelkareemAMAl-ShammariEElkhalifaAEOAdnanMSiddiquiAJSnoussiMet al

Clinical combined risk scores further highlight that environmental exposures during early life have a greater impact on the age of IBD onset than genetic factors, emphasizing that the environment amplifies genetic risk through epigenetics, microbiota, and barrier signaling pathways, playing a dominant role in disease initiation [246]

Thus based on tissue distribution, ALT and GGT would seem to be the most specific markers for liver injury

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