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This enhanced blood flow facilitates nutrient delivery and waste removal at injury sites, accelerating the healing process

For psoriasis specifically, topical application has obvious appeal since the condition manifests on the skin surface

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However, to date, oligonucleotide therapeutics are still facing some technological obstacles, such as how to achieve efficient oligonucleotide delivery to target organs or tissues, how to overcome off-target interactions [4952], and how to address the sequence- and chemistry-dependent toxicity and saturation of endogenous RNA processing pathways [53, 54]

Pretreatment with a Src inhibitor abolished these effects in HUVEC culture, placing Src upstream of the caveolin-1-eNOS step in the proposed cascade