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Most people with Leigh disease have defects in mitochondrial energy production, such as deficiency of mitochondrial respiratory chain enzyme or pyruvate dehydrogenase complex

For more on TMAO see: Egg Industry Response to Choline & TMAO How to Develop a Healthy Gut Ecosystem How Our Gut Bacteria Can Use Eggs to Accelerate Cancer How to Reduce Your TMAO Levels Can Vegan Fecal Transplants Lower TMAO Levels

Transcriptome analysis suggests a compensatory role of the cofactors coenzyme A and NAD+ in medium-chain acyl-CoA dehydrogenase knockout mice