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This function is mediated by fibroblast activation

Mass spectrometry (LC-TQMS) and the proximity extension assay (Olink Cardiovascular III) or individual ELISA panels were used to quantify proteins and metabolites, respectively

Simultaneously, copper overload can lead to loss of mitochondrial membrane potential (m), which triggers cytochrome c release, further activates the intrinsic apoptosis pathway, accelerates cell death and causes tissue damage (140,141)

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Estrogen-related receptor agonism reverses mitochondrial dysfunction and inflammation in the aging kidney